Neurotoxicity of Ecstasy metabolites in rat cortical neurons. Influence of hyperthermia
نویسندگان
چکیده
Affiliation: REQUIMTE, Toxicology Dept., Faculty of Pharmacy, Univ. Porto, Porto, Portugal (J.P.C., F.R., M.L.B., F.C.) Neurology Dept., Charité Hospital, Humboldt Univ., Berlin, Germany (A.M.) REQUIMTE/CQFB, Chemistry Dept., Faculty of Science and Technology, Univ. Nova de Lisboa, Monte de Caparica, Portugal (A.R.A., P.S.B., L.M.F., A.M.L.) JPET Fast Forward. Published on September 23, 2005 as DOI:10.1124/jpet.105.092577
منابع مشابه
Neurotoxicity of Ecstasy metabolites in rat cortical neurons, and influence of hyperthermia.
3,4-Methylenedioxymethamphetamine (MDMA or "Ecstasy") is a widely abused, psychoactive recreational drug. There is growing evidence that the MDMA neurotoxic profile may be highly dependent on both its hepatic metabolism and body temperature. Metabolism of MDMA involves N-demethylation to 3,4-methylenedioxyamphetamine (MDA), which is also a drug of abuse. MDMA and MDA are O-demethylenated to N-m...
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